1 00:00:05,269 --> 00:00:03,169 attic Shiftwell this was a stable and 2 00:00:07,970 --> 00:00:05,279 flat as can be during the stick there 3 00:00:14,589 --> 00:00:07,980 there was no physiological evidence of 4 00:00:17,240 --> 00:00:14,599 him experiencing any pain whatsoever so 5 00:00:20,570 --> 00:00:17,250 what we've basically seen is that the 6 00:00:24,230 --> 00:00:20,580 eegees synchrony the turning on and off 7 00:00:28,400 --> 00:00:24,240 of these rhythms can be mediated by 8 00:00:31,009 --> 00:00:28,410 these DC field potentials but in a 9 00:00:33,560 --> 00:00:31,019 theoretical paper in by Weaver in 10 00:00:35,600 --> 00:00:33,570 nineteen ninety eight he suggested that 11 00:00:38,540 --> 00:00:35,610 we needed at least a hundred micro volt 12 00:00:41,020 --> 00:00:38,550 gradient where a millimeter away from it 13 00:00:46,569 --> 00:00:41,030 you'd have a hundred micro volts less 14 00:00:52,100 --> 00:00:46,579 voltage in the DC field potential and 15 00:00:55,130 --> 00:00:52,110 luckily we've known since 1875 that 16 00:00:57,650 --> 00:00:55,140 animals were capable of 150 to 200 micro 17 00:01:00,410 --> 00:00:57,660 volts per millimeter of field gradient 18 00:01:02,869 --> 00:01:00,420 so we do have enough juice to literally 19 00:01:05,719 --> 00:01:02,879 turn on and off synchrony or the 20 00:01:07,730 --> 00:01:05,729 rhythmic content of the brain and this 21 00:01:12,289 --> 00:01:07,740 can actually happen in the timescale of 22 00:01:14,929 --> 00:01:12,299 a millisecond you can initiate a rhythm 23 00:01:17,120 --> 00:01:14,939 you can create the onset of a rhythm 24 00:01:19,580 --> 00:01:17,130 within a millisecond or so using these 25 00:01:25,219 --> 00:01:19,590 DC field potentials and this is 26 00:01:28,640 --> 00:01:25,229 important the classical definition of 27 00:01:30,560 --> 00:01:28,650 binding that you're going to require a 28 00:01:32,210 --> 00:01:30,570 distant location to be bound with 29 00:01:35,210 --> 00:01:32,220 another location in order for things to 30 00:01:38,330 --> 00:01:35,220 work as an example if I move my hand I'm 31 00:01:40,850 --> 00:01:38,340 literally having a phase locking between 32 00:01:44,630 --> 00:01:40,860 my cerebellum the basal ganglia that 33 00:01:47,020 --> 00:01:44,640 modulate and smooth and help with 34 00:01:51,499 --> 00:01:47,030 movement the frontal lobe which 35 00:01:52,969 --> 00:01:51,509 initiates movement the motor strip this 36 00:01:57,560 --> 00:01:52,979 entire network has to have a 37 00:02:01,340 --> 00:01:57,570 phase-locked operation during the 38 00:02:03,319 --> 00:02:01,350 control of movement so the traditional 39 00:02:06,289 --> 00:02:03,329 view of this is that gamma is the 40 00:02:08,990 --> 00:02:06,299 binding rhythm but I'm here to here to 41 00:02:11,869 --> 00:02:09,000 tell you the heresy that gamma is far 42 00:02:13,790 --> 00:02:11,879 too slow to be the binding principle 43 00:02:16,150 --> 00:02:13,800 gamma emerges 44 00:02:19,340 --> 00:02:16,160 as a resonant property of bound networks 45 00:02:23,540 --> 00:02:19,350 it takes 45 milliseconds which is two 46 00:02:27,530 --> 00:02:23,550 wavelets worth of gamma for it to be 47 00:02:30,080 --> 00:02:27,540 seen in a neural network so it's a 48 00:02:32,450 --> 00:02:30,090 resonant property of having them bound 49 00:02:34,820 --> 00:02:32,460 but it's not the binding principle it's 50 00:02:36,440 --> 00:02:34,830 far too slow if you're going to bind a 51 00:02:39,260 --> 00:02:36,450 network for function you have to bind it 52 00:02:41,210 --> 00:02:39,270 now this millisecond not forty five 53 00:02:44,000 --> 00:02:41,220 milliseconds later after the fact so 54 00:02:45,740 --> 00:02:44,010 gamma emerges from bound networks but 55 00:02:48,830 --> 00:02:45,750 it's not the thing that binds them and 56 00:02:51,830 --> 00:02:48,840 it's easily understood why they've seen 57 00:02:53,690 --> 00:02:51,840 it as the binding rhythm because they've 58 00:02:56,810 --> 00:02:53,700 been looking with 40 a typically and 59 00:02:58,760 --> 00:02:56,820 Fourier smears the time domain and they 60 00:03:01,880 --> 00:02:58,770 don't see the the dynamics of the 61 00:03:03,590 --> 00:03:01,890 Fourier bursting and little chirps we'll 62 00:03:07,190 --> 00:03:03,600 see that in the displays I'm going to 63 00:03:10,100 --> 00:03:07,200 show you a little bit later this is an 64 00:03:12,290 --> 00:03:10,110 example of binding this is a each 65 00:03:15,650 --> 00:03:12,300 electrode in a high-density array has 66 00:03:17,750 --> 00:03:15,660 its own little spot up there and if 67 00:03:19,790 --> 00:03:17,760 you're perceiving something it takes you 68 00:03:23,720 --> 00:03:19,800 about 300 milliseconds to differentiate 69 00:03:27,199 --> 00:03:23,730 one stimulus from another and so let's 70 00:03:29,120 --> 00:03:27,209 say I threw out a double negative and 71 00:03:31,540 --> 00:03:29,130 your English teachers you know you've 72 00:03:34,130 --> 00:03:31,550 suddenly heard a semantic non sequitur 73 00:03:36,020 --> 00:03:34,140 there's a detector in your brain that 74 00:03:40,150 --> 00:03:36,030 will go off when you hear something 75 00:03:42,979 --> 00:03:40,160 that's not right and it's you know 76 00:03:45,290 --> 00:03:42,989 nicely that they refer to as a semantic 77 00:03:49,070 --> 00:03:45,300 non sequitur detector but let me tell 78 00:03:51,350 --> 00:03:49,080 you it's a BS detector yeah yeah when 79 00:03:53,000 --> 00:03:51,360 you hear something that's not right it 80 00:03:55,430 --> 00:03:53,010 takes you three hundred milliseconds to 81 00:03:58,250 --> 00:03:55,440 actually differentiate what you've heard 82 00:04:00,440 --> 00:03:58,260 from something else but at 400 83 00:04:03,440 --> 00:04:00,450 milliseconds your brain is going to have 84 00:04:05,840 --> 00:04:03,450 to identify whether it's BS or not just 85 00:04:08,490 --> 00:04:05,850 before you encode it into memory at 450 86 00:04:10,740 --> 00:04:08,500 milliseconds so 87 00:04:14,460 --> 00:04:10,750 the display that you see up front here 88 00:04:16,229 --> 00:04:14,470 is showing us that as as you approach 89 00:04:20,520 --> 00:04:16,239 this time period there are areas that 90 00:04:24,510 --> 00:04:20,530 are bound in and turned on to evaluate 91 00:04:27,420 --> 00:04:24,520 the the BS in the frontal lobe these are 92 00:04:29,790 --> 00:04:27,430 evaluative areas perceptual areas are 93 00:04:31,950 --> 00:04:29,800 now locked out if you're hearing BS you 94 00:04:33,420 --> 00:04:31,960 don't want to hear anymore BS so you're 95 00:04:36,470 --> 00:04:33,430 literally lock locking out your 96 00:04:39,270 --> 00:04:36,480 perceptual areas in locking in your 97 00:04:41,550 --> 00:04:39,280 evaluative frontal lobe areas and this 98 00:04:45,600 --> 00:04:41,560 happens on an instantaneous basis so 99 00:04:48,780 --> 00:04:45,610 binding is an important function it's 100 00:04:50,520 --> 00:04:48,790 how neural networks actually work and as 101 00:04:52,950 --> 00:04:50,530 a demonstration of it here you can see 102 00:04:57,030 --> 00:04:52,960 areas that are on an instantaneous basis 103 00:04:59,040 --> 00:04:57,040 when you hear something that is BS areas 104 00:05:00,990 --> 00:04:59,050 that evaluated are being turned on and 105 00:05:02,820 --> 00:05:01,000 locked in and areas that are going to 106 00:05:08,340 --> 00:05:02,830 continue to give you more BS are locked 107 00:05:10,680 --> 00:05:08,350 out traditionally again gamma is the 108 00:05:12,480 --> 00:05:10,690 binding rhythm that's the the gospel 109 00:05:13,740 --> 00:05:12,490 according to neurology at this point 110 00:05:16,770 --> 00:05:13,750 it's being taught in most of the 111 00:05:19,530 --> 00:05:16,780 universities but it's BS when I hear it 112 00:05:22,409 --> 00:05:19,540 my somatic non sequitur detector goes 113 00:05:27,840 --> 00:05:22,419 off before they probably start talking 114 00:05:30,860 --> 00:05:27,850 so but it's not the binding rhythm it's 115 00:05:35,310 --> 00:05:30,870 it's a property of being bound 116 00:05:37,680 --> 00:05:35,320 event-related potentials some of you may 117 00:05:40,770 --> 00:05:37,690 not be into EEG and ERPs and all of 118 00:05:42,450 --> 00:05:40,780 these so let's suggest what an ERP 119 00:05:45,570 --> 00:05:42,460 actually is before we talk about them a 120 00:05:49,860 --> 00:05:45,580 little bit you're going to receive this 121 00:05:52,890 --> 00:05:49,870 a sensory input as that reaches the 122 00:05:54,930 --> 00:05:52,900 cortex that's in a vote response that's 123 00:05:57,420 --> 00:05:54,940 like the knee-jerk you know boom that's 124 00:06:00,210 --> 00:05:57,430 a reflex it's just passing the signal up 125 00:06:02,450 --> 00:06:00,220 to the brain but from that point on the 126 00:06:07,100 --> 00:06:02,460 event-related potential is the brains 127 00:06:09,510 --> 00:06:07,110 oscillatory response to that input and 128 00:06:11,190 --> 00:06:09,520 essentially what happens is that at 129 00:06:11,750 --> 00:06:11,200 about a hundred milliseconds you get the 130 00:06:16,340 --> 00:06:11,760 court 131 00:06:18,140 --> 00:06:16,350 arrival of the signal and this is 132 00:06:19,970 --> 00:06:18,150 essentially very very similar to 133 00:06:22,400 --> 00:06:19,980 something called the perceptual frame if 134 00:06:25,670 --> 00:06:22,410 you perceive to stimuli and they're 135 00:06:27,950 --> 00:06:25,680 within about 75 to approximately 100 136 00:06:30,320 --> 00:06:27,960 milliseconds of each other you time lock 137 00:06:33,200 --> 00:06:30,330 them subjectively in your own mind as 138 00:06:35,540 --> 00:06:33,210 having happened at the same moment now 139 00:06:37,340 --> 00:06:35,550 you can perceive a 100 millisecond 140 00:06:40,100 --> 00:06:37,350 difference in time I mean that's not 141 00:06:42,020 --> 00:06:40,110 it's a tenth of a second you can you can 142 00:06:44,240 --> 00:06:42,030 tell something happened in a tenth of a 143 00:06:45,770 --> 00:06:44,250 second but if they happen within a tenth 144 00:06:47,840 --> 00:06:45,780 of a second literally they're bound 145 00:06:51,530 --> 00:06:47,850 together into the same perceptual packet 146 00:06:54,560 --> 00:06:51,540 and the brain processes these packets as 147 00:06:57,590 --> 00:06:54,570 a as a discrete chunk that's being 148 00:07:00,940 --> 00:06:57,600 processed you knit them back together 149 00:07:03,590 --> 00:07:00,950 into a stream that appears to be 150 00:07:07,990 --> 00:07:03,600 continuous but literally you're taking 151 00:07:10,670 --> 00:07:08,000 snapshots of the background of your life 152 00:07:15,020 --> 00:07:10,680 about ten times a second assuming your 153 00:07:17,090 --> 00:07:15,030 alpha frequency is Jen hurts people had 154 00:07:19,130 --> 00:07:17,100 have a faster alpha frequency have a 155 00:07:21,350 --> 00:07:19,140 faster snapshot they have an over 156 00:07:23,750 --> 00:07:21,360 sampling rate that's a little bit better 157 00:07:25,370 --> 00:07:23,760 and in fact they have a better semantic 158 00:07:28,550 --> 00:07:25,380 memory performance and typically a 159 00:07:30,920 --> 00:07:28,560 higher intelligence this work is out of 160 00:07:36,680 --> 00:07:30,930 salzburg austria a wolfgang klemish as 161 00:07:40,330 --> 00:07:36,690 lab in salzburg the this 100 millisecond 162 00:07:43,700 --> 00:07:40,340 time frame also has the initial 163 00:07:46,010 --> 00:07:43,710 processing of sensory inputs the 164 00:07:49,580 --> 00:07:46,020 Association cortex immediately adjacent 165 00:07:52,550 --> 00:07:49,590 to the primary sensory area receives the 166 00:07:55,760 --> 00:07:52,560 relay and the immediate surround in 167 00:07:58,160 --> 00:07:55,770 about that same time frame and the 168 00:08:00,290 --> 00:07:58,170 stimulus azhar projected up from the 169 00:08:02,450 --> 00:08:00,300 sensory areas in the back of the head up 170 00:08:04,610 --> 00:08:02,460 to the prefrontal and sensory 171 00:08:06,560 --> 00:08:04,620 integration areas the frontal areas are 172 00:08:09,200 --> 00:08:06,570 a valued of the parietal areas are 173 00:08:11,750 --> 00:08:09,210 sensory integration shortly thereafter 174 00:08:15,590 --> 00:08:11,760 so the brain is starting to actually 175 00:08:17,150 --> 00:08:15,600 process these pieces of information but 176 00:08:19,470 --> 00:08:17,160 the event-related potential has a 177 00:08:21,030 --> 00:08:19,480 specific morphology 178 00:08:23,820 --> 00:08:21,040 I'd like to mention it right now 179 00:08:25,890 --> 00:08:23,830 essentially if you phase reset or press 180 00:08:28,470 --> 00:08:25,900 the reset button and start alpha 181 00:08:30,930 --> 00:08:28,480 frequencies and theta frequencies at the 182 00:08:33,240 --> 00:08:30,940 same time add the two waveforms together 183 00:08:36,510 --> 00:08:33,250 and let them free run you get the wave 184 00:08:39,680 --> 00:08:36,520 shape of the event-related potential the 185 00:08:42,900 --> 00:08:39,690 DC field potentials can phase reset or 186 00:08:45,300 --> 00:08:42,910 initiate oscillatory activity within a 187 00:08:47,700 --> 00:08:45,310 millisecond so that the DC field 188 00:08:49,530 --> 00:08:47,710 potentials are literally hitting a reset 189 00:08:53,790 --> 00:08:49,540 button so that your brain can then 190 00:08:57,720 --> 00:08:53,800 process this activity the importance of 191 00:09:00,570 --> 00:08:57,730 this is that you have two basic systems 192 00:09:04,850 --> 00:09:00,580 within your brain that function for 193 00:09:08,970 --> 00:09:04,860 memory memory requires the frontal lobe 194 00:09:11,940 --> 00:09:08,980 and limbic systems theta frequencies 195 00:09:14,070 --> 00:09:11,950 which are slower as well as the more 196 00:09:16,050 --> 00:09:14,080 posterior alpha frequencies and they 197 00:09:18,900 --> 00:09:16,060 have to interact the frontal lobe is 198 00:09:21,540 --> 00:09:18,910 your working memory theta is associated 199 00:09:23,070 --> 00:09:21,550 with working memory and retrieval the 200 00:09:24,930 --> 00:09:23,080 Alpha frequencies on the back of the 201 00:09:27,390 --> 00:09:24,940 head are associated with semantic memory 202 00:09:30,870 --> 00:09:27,400 but for memory to work you have to take 203 00:09:32,930 --> 00:09:30,880 stuff from short-term hold the working 204 00:09:36,330 --> 00:09:32,940 memory and put it into long-term memory 205 00:09:39,210 --> 00:09:36,340 so if those two systems didn't have a 206 00:09:41,490 --> 00:09:39,220 method of interaction there'd be no data 207 00:09:45,090 --> 00:09:41,500 transfer between your working memory and 208 00:09:48,090 --> 00:09:45,100 your long-term memory and as Capri Bream 209 00:09:53,670 --> 00:09:48,100 has identified the memory storage itself 210 00:09:55,920 --> 00:09:53,680 is hollow holonomic holographic is what 211 00:09:58,800 --> 00:09:55,930 you put on a plate that holonomic is is